Mitsuharu Ueda Selected Research

Polyneuropathies (Polyneuropathy)

12/2023	Disease-Modifying Drugs Extend Survival in Hereditary Transthyretin Amyloid Polyneuropathy.
7/2023	Treatment response and neurofilament light chain levels with long-term patisiran in hereditary transthyretin-mediated amyloidosis with polyneuropathy: 24-month results of an open-label extension study.
1/2021	Long-term safety and efficacy of patisiran for hereditary transthyretin-mediated amyloidosis with polyneuropathy: 12-month results of an open-label extension study.
3/2020	Analysis of autonomic outcomes in APOLLO, a phase III trial of the RNAi therapeutic patisiran in patients with hereditary transthyretin-mediated amyloidosis.
1/2020	Characteristics of Patients with Hereditary Transthyretin Amyloidosis and an Evaluation of the Safety of Tafamidis Meglumine in Japan: An Interim Analysis of an All-case Postmarketing Surveillance.
1/2018	Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis.
3/2017	Long-term effects of liver transplantation on small-fiber dysfunction in Japanese transthyretin (ATTR) V30M hereditary amyloidosis with polyneuropathy (FAP).
11/2016	Novel Antibody for the Treatment of Transthyretin Amyloidosis.
1/2016	Long-term outcome of patients with hereditary transthyretin V30M amyloidosis with polyneuropathy after liver transplantation.
3/2014	Generation of familial amyloidotic polyneuropathy-specific induced pluripotent stem cells.

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Mitsuharu Ueda Research Topics

Disease

110	Amyloidosis 05/2024 - 08/2005
39	Polyneuropathies (Polyneuropathy) 12/2023 - 02/2004
27	Cardiomyopathies (Cardiomyopathy) 05/2024 - 09/2016
26	Transthyretin-Related Hereditary Amyloidosis 04/2024 - 11/2011
25	Amyloid Plaque 12/2022 - 02/2004
21	Familial Amyloid Neuropathies (Familial Amyloid Polyneuropathy) 01/2020 - 01/2005
15	Neoplasms (Cancer) 04/2023 - 08/2009
11	Familial Amyloidosis (Hereditary Amyloidosis) 05/2023 - 05/2008
9	Immunoglobulin Light-chain Amyloidosis 05/2024 - 01/2009
8	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 02/2024 - 10/2017
8	Squamous Cell Carcinoma of Head and Neck 01/2015 - 09/2009
7	Disease Progression 07/2023 - 03/2017
7	Carpal Tunnel Syndrome 01/2023 - 01/2018
6	Heart Failure 05/2024 - 01/2019
5	Hemorrhage 01/2024 - 01/2009
5	Alzheimer Disease (Alzheimer's Disease) 09/2022 - 01/2012
5	Dementia (Dementias) 08/2022 - 10/2017
4	Atrial Fibrillation 03/2024 - 01/2022
4	Stroke (Strokes) 01/2023 - 12/2020
4	Cerebral Hemorrhage 08/2022 - 10/2017
4	Autonomic Nervous System Diseases (Dysautonomia) 01/2022 - 06/2006
4	Aortic Valve Stenosis (Aortic Stenosis) 01/2022 - 07/2020
3	Amyloid Neuropathies (Amyloid Neuropathy) 12/2023 - 03/2017
3	Hypertrophy 11/2023 - 05/2013
3	CADASIL 01/2022 - 08/2017
3	Cardiomegaly (Heart Hypertrophy) 01/2022 - 05/2013
3	Syndrome (Syndromes) 01/2021 - 01/2018
3	Inflammation (Inflammations) 01/2017 - 09/2005
2	Myotonic Dystrophy (Dystrophia Myotonica) 11/2023 - 11/2022
2	Pain (Aches) 11/2023 - 07/2018
2	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 01/2023 - 01/2019
2	Hypertension (High Blood Pressure) 12/2022 - 12/2020
2	COVID-19 01/2022 - 12/2020
2	Multiple Myeloma 01/2022 - 03/2015
2	Pathologic Constriction (Stenosis) 06/2021 - 02/2015
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 05/2021 - 03/2006
2	Rheumatoid Arthritis 03/2021 - 10/2010
2	Insulin Resistance 01/2019 - 01/2015
2	Atrophy 01/2016 - 01/2005
2	Glioblastoma (Glioblastoma Multiforme) 08/2014 - 08/2009
2	Peripheral Nervous System Diseases (PNS Diseases) 01/2014 - 06/2006
2	Neoplasm Metastasis (Metastasis) 03/2012 - 09/2009

Drug/Important Bio-Agent (IBA)

130	Prealbumin (Transthyretin)IBA 05/2024 - 02/2004
86	Amyloid (Amyloid Fibrils)IBA 05/2024 - 02/2004
32	Proteins (Proteins, Gene)FDA Link 01/2024 - 02/2004
10	tafamidisIBA 05/2024 - 03/2016
10	diphosphoric acid (pyrophosphoric acid)IBA 01/2024 - 01/2019
10	Amyloidogenic ProteinsIBA 04/2023 - 05/2008
9	Biomarkers (Surrogate Marker)IBA 05/2024 - 11/2014
8	AntibodiesIBA 09/2023 - 04/2013
7	Immunoglobulin Light Chains (Immunoglobulin Light Chain)IBA 05/2024 - 01/2016
7	Congo RedIBA 09/2023 - 03/2006
7	Troponin T (Troponin T1)IBA 01/2022 - 01/2018
5	Therapeutic UsesIBA 05/2024 - 03/2016
5	patisiranIBA 07/2023 - 01/2018
5	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2022 - 01/2018
5	MidkineIBA 05/2012 - 09/2009
4	Small Interfering RNA (siRNA)IBA 12/2023 - 08/2009
4	Messenger RNA (mRNA)IBA 11/2023 - 09/2009
4	fibulinIBA 01/2022 - 01/2019
4	Extracellular Matrix ProteinsIBA 01/2022 - 01/2019
4	Epidermal Growth Factor (EGF)IBA 01/2022 - 01/2019
4	Interleukin-6 (Interleukin 6)IBA 01/2017 - 08/2009
3	Peptides (Polypeptides)IBA 01/2024 - 01/2017
3	Protein AggregatesIBA 10/2023 - 01/2022
3	CyclodextrinsIBA 09/2022 - 07/2011
3	Dendrimers (Dendrons)IBA 09/2022 - 01/2019
3	GadoliniumIBA 01/2022 - 06/2017
3	CytokinesIBA 08/2014 - 11/2006
3	AA amyloidosisIBA 01/2012 - 11/2006
3	tocilizumab (atlizumab)FDA Link 09/2011 - 08/2009
3	Interleukin-6 Receptors (Interleukin 6 Receptor)IBA 09/2011 - 08/2009
2	RNA (Ribonucleic Acid)IBA 11/2023 - 01/2022
2	Immunoglobulins (Immunoglobulin)IBA 09/2023 - 03/2016
2	Technetium (Technetium 99m)IBA 09/2023 - 01/2022
2	Technetium Tc 99m PyrophosphateIBA 01/2023 - 01/2020
2	ApolipoproteinsIBA 12/2022 - 01/2019
2	AlbuminsIBA 06/2022 - 08/2011
2	Dexamethasone (Maxidex)FDA LinkGeneric 01/2022 - 01/2016
2	Lenalidomide (CC 5013)FDA Link 01/2022 - 01/2016
2	Apolipoprotein A-I (Apolipoprotein A1)IBA 06/2021 - 01/2016
2	Insulysin (Insulin-Degrading Enzyme)IBA 01/2021 - 12/2019
2	Islet Amyloid PolypeptideIBA 01/2021 - 08/2012
2	Amyloid beta-PeptidesIBA 12/2019 - 10/2017
2	Blood Proteins (Serum Proteins)IBA 01/2019 - 07/2016
2	Insulin (Novolin)FDA Link 01/2019 - 01/2015
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 08/2014 - 09/2009
2	EpitopesIBA 03/2014 - 06/2012
2	Heparin (Liquaemin)FDA LinkGeneric 05/2012 - 09/2009
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 05/2012 - 09/2009
2	Monoclonal AntibodiesIBA 03/2012 - 01/2009
1	benziodaroneIBA 04/2024

Therapy/Procedure

24	Liver Transplantation 03/2024 - 02/2004
21	Therapeutics 01/2024 - 09/2011
4	Drug Therapy (Chemotherapy) 02/2024 - 01/2011
4	Transplantation 07/2020 - 03/2006
3	Lasers (Laser) 01/2022 - 01/2017
3	RNAi Therapeutics 03/2020 - 01/2018
2	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 01/2019 - 09/2011
2	Denervation 01/2019 - 06/2017